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Deoxycorticosterone acetate

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产品编号 T3033Cas号 56-47-3
别名 醋酸脱氧皮质酮, 醋酸去氧皮质酮, DOC acetate, Cortexone acetate, 11-Deoxycorticosterone acetate

Deoxycorticosterone acetate (Cortexone acetate) 是肾上腺产生的类固醇激素,具有盐皮质激素活性,并作为醛固酮的前体。

Deoxycorticosterone acetate

Deoxycorticosterone acetate

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纯度: 99.81%
产品编号 T3033 别名 醋酸脱氧皮质酮, 醋酸去氧皮质酮, DOC acetate, Cortexone acetate, 11-Deoxycorticosterone acetateCas号 56-47-3

Deoxycorticosterone acetate (Cortexone acetate) 是肾上腺产生的类固醇激素,具有盐皮质激素活性,并作为醛固酮的前体。

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50 mg¥ 253现货
100 mg¥ 418现货
500 mg¥ 997期货
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纯度:99.81%
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产品介绍

生物活性
产品描述
Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid.
激酶实验
Kinase inhibition: The ability of compounds to inhibit ATR, ATM or DNAPK kinase activity istested using a radiometric-phosphate incorporation assay. A stock solution isprepared consisting of the appropriate buffer, kinase, and target peptide. To this isadded the compound of interest, at varying concentrations in DMSO to a final DMSO concentration of 7%. Assays are initiated by addition of an appropriate [γ-33P]ATP solution and incubated at 25 ℃. Assays are stopped, after the desired time course, by addition of phosphoric acid and ATP to a final concentration of 100 mM and 0.66 μM, respectively. Peptides are captured on a phosphocellulose membrane, prepared as per manufacturer's instructions, and washed six times with 200 μL of 100 mM phosphoric acid, prior to the addition of 100 μL of scintillation cocktail and scintillation counting on a 1450 Microbeta Liquid Scintillation Counter. Dose?response data are analyzed using GraphPad Prism software
别名醋酸脱氧皮质酮, 醋酸去氧皮质酮, DOC acetate, Cortexone acetate, 11-Deoxycorticosterone acetate
化学信息
分子量372.5
分子式C23H32O4
CAS No.56-47-3
Smiles[H][C@@]12CC[C@H](C(=O)COC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
密度1.0415 g/cm3 (Estimated)
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 3.72 mg/mL (10 mM), Sonication is recommended.
Ethanol: 6 mg/mL (16.1 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
溶液配制表
1mg5mg10mg50mg
1 mM2.6846 mL13.4228 mL26.8456 mL134.2282 mL
5 mM0.5369 mL2.6846 mL5.3691 mL26.8456 mL
10 mM0.2685 mL1.3423 mL2.6846 mL13.4228 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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